業績【2001〜2018】

2018年

1. M. Torii, Y. Hitora, H. Kato, Y. Koyanagi, T. Kawahara, F. Losung, R. E. P. Mangindaan, S. Tsukamoto. Siladenoserinols M–P, sulfonated serinol derivatives from a tunicate. Tetrahedron accepted.

2. H. Kato, A. H. El-Desoky, Y. Takeishi, T. Nehira, E. D. Angkouw, R. E. P. Mangindaan, N. J. de Voogd, S. Tsukamoto. Tetradehydrohalicyclamine B, a new proteasome inhibitor from the marine sponge Acanthostrongylophora ingens. Bioorg. Med. Chem. Lett.accepted.

3. A. Fukumoto, Y. Hitora, A. Kai, H. Kato, E. D. Angkouw, R. E. P. Mangindaan, N. J. de Voogd, S. Tsukamoto. Isolation of aaptic acid from the marine sponge Aaptos lobata and inhibitory effect of aaptamines on RANKL-induced formation of multinuclear osteoclasts. Heterocycles in press.

4. A. Kai, H. Kato, D. H. Sherman, R. M. Williams, S. Tsukamoto. Isolation of a new indoxyl alkaloid, Amoenamide B, from Aspergillus amoenus NRRL 35600: biosynthetic implications and correction of the structure of Speramide B. Tetrahedron Lett. 59 (48), 4236-4240 (2018).

5. S. Shiomi, K. Wada, Y. Umeda, H. Kato, S. Tsukamoto, H. Ishikawa. Total syntheses and stereochemical reassignments of mollenines A and B. Bioorg. Med. Chem. Lett. 28 (16), 2766-2769 (2018).

6. M. Inoue, Y. Hitora, H. Kato, F. Losung, R. E. P. Mangindaan, S. Tsukamoto. New geranyl flavonoids from the leaves of Artocarpus communis. J. Nat. Med. 72 (3), 632-640 (2018).

7. M. Yoshida, K. Saito, H. Kato, S. Tsukamoto, T. Doi. A total synthesis and biological evaluation of siladenoserinol A and its analogues. Angew. Chem. Int. Ed. 57 (18), 5147-5150 (2018).

8. A. A. El-Beih, A. H. El-Desoky, M. A. Al-hammady, A.-S. I. Elshamy, M.-E. F. Hegazy, H. Kato, S. Tsukamoto. New inhibitiors of RANKL-induced osteoclastogenesis from the marine sponge Siphonochalina siphonella. Fitoterapia128, 43-49 (2018).

9. M. Hashimoto, H. Kato, A. Katsuki, S. Tsukamoto, I. Fujii. Identification of biosynthetic gene cluster for himeic acid A, a ubiquitin-activating enzyme (E1) inhibitor, in Aspergillus japonicus MF275. ChemBioChem 19 (6), 535-539 (2018).

10. A. Katsuki, H. Kato, Y. Tahara, M. Hashimoto, I. Fujii, S. Tsukamoto. pH-Dependent production of himeic acid A and its non-enzymatic conversions to himeic acids B and C. Bioorg. Med. Chem. 26 (8), 1869-1874 (2018).

Reviews

1. K. Klas, H. Kato, J. C. Frisvad, F. Yu, S. Newmister, A. Fraley, D. H. Sherman, S. Tsukamoto, R. M. Williams. Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring system from marine and terrestrial fungi. Nat. Prod. Rep. 35 (6), 532-558 (2018).

2017年

1. Kato, H., Kai, A., Kawabata, T., Sunderhaus, J. D., McAfoos, T. J., Finefield, J. M., Sugimoto, Y., Williams, R. M., Tsukamoto, S. Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts. Bioorg. Med. Chem. Lett. 27 (22), 4975-4978 (2017).

2. Torii, M., Kato, H., Hitora, Y., Angkouw, E. D., Mangindaan, R. E. P., de Voogd, N. J., Tsukamoto, S. Lamellodysidines A and B, sesquiterpenes isolated from the marine sponge Lamellodysidea herbacea. J. Nat. Prod. 80 (9), 2536-2541 (2017).

3. El-Desoky, A. H., Kato, H., Tsukamoto, S. Ceylonins G−I: Spongian diterpenes from the marine sponge Spongia ceylonensis. J. Nat. Med. 71 (4), 765-769 (2017).

4. Afifi, A. H., Kagiyama, I., El-Desoky, A. H., Kato, H., Mangindaan, R. E. P., de Voogd, N. J., Ammar, N. M., Hifnawy, M. S., Tsukamoto, S. Sulawesins A–C, furanosesterterpene tetronic acids that inhibit USP7, from a Psammocinia sp. marine sponge. J. Nat. Prod. 80 (7), 2045-2050 (2017).

5. Sugimoto, K., Sadahiro, Y., Kagiyama, I., Kato, H., Sherman, D. H., Williams, R. M., Tsukamoto, S. Isolation of amoenamide A and five antipodal prenylated alkaloids from Aspergillus amoenus NRRL 35600. Tetrahedron Lett. 58 (29), 2797-2800 (2017).

6. El-Desoky, A. H., Kato, H., Kagiyama, I., Hitora, Y., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Tsukamoto, S. Ceylonins A-F, spongian diterpene derivatives that inhibit RANKL-induced formation of multinuclear osteoclasts, from the marine sponge Spongia ceylonensis. J. Nat. Prod. 80 (1), 90-95 (2017).

Book

1. 塚本佐知子. 第II部 アルカロイドの生合成、第8章真菌が産生するノトアミドの生合成「DAS⑧ アルカロイドの科学 —生物活性を生みだす物質の探索から創薬の実際まで—」、編集:高山廣光、pp. 149-166、化学同人 (2017)

2016年

1. El-Desoky, A. H., Kato, H., Angkouw, E. D., Mangindaan, R. E. P., de Voogd, N. J., Tsukamoto, S. Ceylonamides A-F, nitrogenous spongian diterpenes that inhibit RANKL-induced osteoclastogenesis, from the marine sponge Spongia ceylonensis. J. Nat. Prod. 79 (8), 1922-1928 (2016).

2. Tanokashira, N., Kukita, S., Kato, H., Nehira, T., Angkouw, E. D., Mangindaan, R. E. P., de Voogd, N. J., Tsukamoto, S. Petroquinones: Trimeric and dimeric xestoquinone derivatives isolated from the marine sponge Petrosia alfiani. Tetrahedron 72 (35), 5530-5540 (2016).

3. Afifi, A. H., El-Desoky, A. H., Kato, H., Mangindaan, R. E. P., de Voogd, N. J., Ammar, N. M., Hifnawy, M. S., Tsukamoto, S. Carteritins A and B, cyclic heptapeptides from the marine sponge Stylissa carteri. Tetrahedron Lett. 57 (11), 1285-1288 (2016).

4. Kagiyama, I., Kato, H., Nehira, T., Frisvad, J. C., Sherman, D. H., Williams, R. M., Tsukamoto, S. Taichunamides: prenylated indole alkaloids from Aspergillus taichungensis (IBT 19404). Angew. Chem. Int. Ed. 55 (3), 1128-1132 (2016).

5. Tadano, S., Sugimachi, Y., Sumimoto, M., Tsukamoto, S., Ishikawa, H. Collective synthesis and biological evaluation of tryptophan-based dimeric diketopiperazine alkaloids. Chem. Eur. J. 22 (4), 1277-1291 (2016).

Reviews

1. Tsukamoto, S. Search for inhibitors of the ubiquitin-proteasome system from natural sources for cancer therapy. Chem. Pharm. Bull. 64 (2), 112-118 (2016).

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2015年

1. Eguchi, K., Kato, H., Fujiwara, Y., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Takeya, M., Tsukamoto, S. Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages. Bioorg. Med. Chem. Lett. 25 (22) 5389-5392 (2015).

2. Gushiken, M., Kagiyama, I., Kato, H., Kuwana, T., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Tsukamoto, S. Manadodioxans A-E, polyketide endoperoxides from the marine sponge Plakortis bergquistae. J. Nat. Med. 69 (4), 595-600 (2015).

3. Kato, H., Nehira, K., Matsuo, K., Kawabata, T., Kobashigawa, Y., Morioka, H., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Yokosawa, H., Tsukamoto, S. Niphateolide A: Isolation from the Marine Sponge Niphates olemda and Determination of its Absolute Configuration by an ECD Analysis. Tetrahedron 71 (38), 6956-6960 (2015).

4. Takamoto, H., Eguchi, K., Kawabata, T., Fujiwara, Y., Takeya, M., Tsukamoto, S. Inhibitors for Cholesterol Ester Accumulation in Macrophages from Chinese Cabbage. Biosci. Biotechnol. Biochem. 79 (8), 1315-1319 (2015).

5. Noda, A., Sakai, E., Kato, H., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Yokosawa, H., Tsukamoto, S. Strongylophorines, meroditerpenoids from the marine sponge Petrosia corticata, function as proteasome inhibitors. Bioorg. Med. Chem. Lett. 25 (13), 2650-2653 (2015).

6. Kato, H., Nakahara, T., Sugimoto, K., Matsuo, K., Kagiyama, I., Frisvad, J. C., Sherman, D. H., Williams, R. M., Tsukamoto, S. Isolation of Notoamide S and Enantiomeric 6-epi-Stephacidin A from the Fungus Aspergillus amoenus: Biogenetic Implications. Org. Lett. 17 (3), 700-703 (2015).

7. Kato, H., Nakahara, T., Yamaguchi, M., Kagiyama, I., Finefield, J. M., Sunderhaus, J. D., Sherman, D. H., Williams, R. M., Tsukamoto, S. Bioconversion of 6-epi-Notoamide T Produces Metabolites of Unprecedented Structures in a Marine-derived Aspergillus sp. Tetrahedron Lett. 56 (1), 247-251 (2015).

Reviews

1. Klas, K., Tsukamoto, S., Sherman, D. H., Williams, R. M. Natural Diels−Alderases: Elusive and Irresistable (Perspective in The Journal of Organic Chemistry’s Special Issue “50 Years and Counting: The Woodward−Hoffmann Rules in the 21st Century”). J. Org. Chem. 80 (23), 11672-11685 (2015).

2. Sherman, D. H., Tsukamoto, S., Williams, R. M. Comment on “Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence”. Science (Technical Comment), 349 (6244), 149 (2015).

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2014年

1. Yamakuma, M., Kato, H., Matsuo, K., El-Desoky, A. H., Kawabata, T., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Yokosawa, H., Tsukamoto, S. 1-Hydroxyethylhalenaquinone: a New Proteasome Inhibitor from the Marine Sponge Xestospongia sp. Heterocycles 89 (11), 2605-2610 (2014).

2. Tsukamoto, S., Takeuchi, T., Kawabata, T., Kato, H., Yamakuma, M., Matsuo, K., El-Desoky, A. H., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Arata, Y., Yokosawa, H. Halenaquinone Inhibits RANKL-induced Osteoclastogenesis. Bioorg. Med. Chem. Lett. 24 (22), 5315-5317 (2014).

3. Furusato, A., Kato, H., Nehira, T., Eguchi, K., Kawabata, T., Fujiwara, Y., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Takeya, M., Yokosawa, H., Tsukamoto, S. Acanthomanzamines A-E with New Manzamine Frameworks from the Marine Sponge Acanthostrongylophora ingens. Org. Lett. 16 (15), 3888-3891 (2014).

4. El-Desoky, A. H., Kato, H., Eguchi, K., Kawabata, T., Fujiwara, Y., Losung, F., Mangindaan, R. E. P., de Voogd, N., Takeya, M., Yokosawa, H., Tsukamoto, S. Acantholactam and Pre-neo-kauluamine, Manzamine-related Alkaloids, from the Indonesian Marine Sponges, Acanthostrongylophora ingens. J. Nat. Prod. 77 (6), 1536-1540 (2014).

5. Kudo, Y., Kato, H., Rotinsulu, H., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Tsukamoto, S. Aaptoline A, a New Quinoline Alkaloid from the Marine Sponge Aaptos suberitoides. Heterocycles 88 (1), 591-594 (2014).

6. Sakai, E., Kato, H., Rotinsulu, H., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Yokosawa, H., Tsukamoto, S. Variabines A and B, New β-Carboline Alkaloids from the Marine Sponge Luffariella variabilis. J. Nat. Med. 68 (1), 215-219 (2014).

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2013年

1. Imada, K., Sakai, E., Kato, H., Kawabata, T., Yoshinaga, S., Nehira, T., Terasawa, H., Tsukamoto, S. Reticulatins A and B and Hyrtioreticulin F from the Marine Sponge Hyrtios reticulatus. Tetrahedron 69 (34), 7051-7055 (2013).

2. Yamaguchi, M., Miyazaki, M., Kodrasov, M. P., Rotinsulu, H., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Yokosawa, H., Nicholson, B., Tsukamoto, S. Spongiacidin C, a Bromopyrrole Alkaloid from the Marine Sponge Stylissa massa, Functions as a USP7 Inhibitor. Bioorg. Med. Chem. Lett. 23 (13), 3884-3886 (2013).

3. Eguchi, K., Fujiwara, Y., Hayashida, A., Horlad, H., Kato, H., Rotinsulu, H., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Takeya, M., Tsukamoto, S. Manzamine A, a Marine-Derived Alkaloid, Inhibits Accumulation of Cholesterol Ester in Macrophages and Suppresses Hyperlipidemia and Atherosclerosis in vivo. Bioorg. Med. Chem. 21 (13), 3831-3838 (2013).

4. Nakamura, Y., Kato, H., Nishikawa, T., Iwasaki, N., Suwa, Y., Rotinsulu, H., Losung, F., Maarisit, W., Mangindaan, R. E. P., Morioka, H., Yokosawa, H., Tsukamoto, S. Siladenoserinols A-L: New Sulfonated Serinol Derivatives from a Tunicate as Inhibitors of p53-Hdm2 Interaction. Org. Lett. 15 (2), 322-325 (2013).

5. Sunderhaus, J. D., McAfoos, T. J., Finefield, J. M., Kato, H., Li, S., Tsukamoto, S., Sherman, D. H., Williams, R. M. Synthesis and Bioconversions of Notoamide T: A Biosynthetic Precursor to Stephacidin A and Notoamide B. Org. Lett. 15 (1), 22-25 (2013).

6. Kuwana, T., Miyazaki, M., Kato, H., Tsukamoto, S. Himeic Acids E-G, New 4-Pyridone Derivatives from a Culture of Aspergillus sp. Chem. Pharm. Bull. 61 (1), 105-107 (2013).

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2012年

1. Ushiyama, S., Umaoka, H., Kato, H., Suwa, Y., Morioka, H., Rotinsulu, H., Losung, F., Mangindaan, R. E. P., de Voogd, N. J., Yokosawa, H., Tsukamoto, S. Manadosterols A and B, Sulfonated Sterol Dimers Inhibiting Ubc13-Uev1A Interaction, Isolated from the Marine Sponge Lissodendryx fibrosa. J. Nat. Prod. 75 (8), 1495-1499 (2012).

2. Yamanokuchi, R., Imada, K., Miyazaki, M., Kato, H., Watanabe, T., Fujimuro, M., Saeki, Y., Yoshinaga, S., Terasawa, H., Iwasaki, N., Rotinsulu, H., Losung, F., Mangindaan, R. E. P., Namikoshi, M., de Voogd, N. J., Yokosawa, H., Tsukamoto, S. Hirtioreticulins A-E: Indole Alkaloids Inhibiting the Ubiquitin-activating Enzyme, from the Marine Sponge Hyrtios reticulatus. Bioorg. Med. Chem. 20 (14), 4437-4442 (2012).

3. Li, S., Srinivasan, K., Tran, H., Yu, F., Finefield, J. M., Sunderhaus, J. D., McAfoos, T. J., Tsukamoto, S., Williams, R. M., Sherman, D. H. Comparative Analysis of the Biosynthetic Systems for Fungal Bicyclo[2.2.2]diazaoctane Indole Alkaloids: the (+)/(-)-Notoamide, Paraherquamide and Malbrancheamide Pathways. MedChemComm 3 (8), 987-996 (2012).

4. Tamai, Y., Toume, K., Arai, M. A., Hayashida, A., Kato, H., Shizuri, Y., Tsukamoto, S., Ishibashi, M. Nonactin and Related Compounds Found in a Screening Program for Wnt Signal Inhibitory Activity. Heterocycles 84 (2), 1245-1250 (2012).

Review

1. 塚本佐知子、横沢英良. ユビキチン修飾系を標的とする創薬シーズの探索. 実験医学増刊「シグナル伝達 研究最前線2012」、編集:井上純一郎、武川睦寛、徳永文稔、今井浩三、羊土社、30 (5), 171-176 (2012).

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2011年

1. Kato, H., Nakamura, Y., Finefield, J. M., Umaoka, H., Nakahara, T., Williams, R. M., Tsukamoto, S. Study on the Biosynthesis of the Notoamides: Pinacol-type Rearrangement of Isoprenyl Unit in Deoxybrevianamide E and 6-Hydroxydeoxybrevianamide E. Tetrahedron Lett. 52 (51), 6923-6926 (2011).

2. Nagasawa, Y., Kato, H., Rotinsulu, H., Mangindaan, R. E. P., de Voogd, N. J., Tsukamoto, S. Spironaamidine, a New Spiroquinone-containing Alkaloid from the Marine Sponge Leucetta microraphis. Tetrahedron Lett. 52 (41), 5342-5344 (2011).

3. Finefield, J. M., Kato, H., Greshock, T. J., Sherman, D. H., Tsukamoto, S., Williams, R. M. Biosynthetic Studies of the Notoamides: Isotopic Synthesis of Stephacidin A and Incorporation into Notoamide B and Sclerotiamide. Org. Lett. 13 (15), 3802-3805 (2011).

4. Finefield, J. M., Sherman, D. H., Tsukamoto, S., Williams, R. M. Studies on the Biosynthesis of the Notoamides: Synthesis of an Isotopomer of 6-Hydroxydeoxybrevianamide E and Biosynthetic Incorporation into Notoamide J. J. Org. Chem. 76 (15), 5954-5958 (2011).

5. Fujiwara, Y., Hayashida, A., Tsurushima, K., Nagai, R., Yoshitomi, M., Sakashita, N., Takeya, M., Tsukamoto, S., Ikeda, T. Triterpenes Isolated from Zizyphus Jujuba Inhibit the Foam Cell Formation in Macrophages. J. Agric. Food Chem. 59 (9), 4544-4552 (2011).

6. Finefield, J. M., Greshock, T. J., Sherman, D. H., Tsukamoto, S., Williams, R. M. Notoamide E: Biosynthetic incorporation into notoamides C and D in cultures of Aspergillus versicolor NRRL 35600. Tetrahedron Lett. 52 (16), 1987-1989 (2011).

7. Hirata, T., Kobayashi, T., Wada, A., Ueda, T., Fujikawa, T., Miyashita, H., Ikeda, T., Tsukamoto, S., Nohara, T. Anti-obesity Compounds in Green Leaves of Eucommia ulmoides. Bioorg. Med. Chem. Lett. 21 (6), 1786-1791 (2011).

8. Nagasawa, Y., Ueoka, R., Yamanokuchi, R., Horiuchi, N., Ikeda, T., Rotinsulu, H., Mangindaan, R. E. P., Ukai, K., Kobayashi, H., Namikoshi, M., Hirota, H., Yokosawa, H., Tsukamoto, S. Isolation of Salsolinol, a Tetrahydroisoquinoline Alkaloid, from the Marine Sponge Xestospongia cf. vansoesti as a Proteasome Inhibitor. Chem. Pharm. Bull. 59 (2), 287-290 (2011).

Review

1. 塚本佐知子、横沢英良. ユビキチン依存的タンパク質分解系を標的とする創薬. 化学と生物、 49 (11), 745-754 (2011).

Book

1. 塚本佐知子. 第2章 医薬素材および試薬、3.無脊椎動物、マリンバイオテクノロジーの新展開、監修:伏谷伸宏、シーエムシー出版、印刷中 (2011).

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2010年

1. McAfoos, T. J., Tsukamoto, S., Sherman, D. H., Williams, R. M. Studies on the Biosynthesis of the Stephacidins and Notoamides. Total Synthesis of Notoamide S. Heterocycles 82 (1), 461-472 (2010).

2. Ding, Y., de Wet, J. R., Cavalcoli, J., Li, S., Greshock, T. J., Miller, K. A., Finefield, J. M., Sunderhaus, J. D., McAfoos, T. J., Tsukamoto, S., Williams, R. M., Sherman, D. H. Genome-based Characterization of Two Prenylation Steps in the Assembly of the Stephacidin and Notoamide Anticancer Agents in a Marine Aspergillus sp. J. Am. Chem. Soc. 132 (36), 12733-12740 (2010).

3. Tsukamoto, S., Umaoka, H., Yoshikawa, K., Ikeda, T., Hirota, H. Notoamide O, a Structurally Unprecedented Prenylated Indole Alkaloid, and Notoamides P-R from a Marine-derived Fungus, Aspergillus sp. J. Nat. Prod. 73 (8), 1438-1440 (2010).

4. El-Aasr, M., Fujiwara, Y., Takeya, M., Ikeda, T., Tsukamoto, S., Ono, M., Nakano, D., Okawa, M., Kinjo, J., Yoshimitsu, H., Nohara, T. Onionin A from Allium cepa Controls Macrophage Activation. J. Nat. Prod. 73 (7), 1306-1308 (2010).

5. Tsukamoto, S., Yamanokuchi, R., Yoshitomi, M., Sato, K., Ikeda, T., Rotinsulu, H., Mangindaan, R. E. P., de Voogd, N. J., van Soest, R. W. M., Yokosawa, H. Aaptamine, an Alkaloid from the Sponge Aaptos suberitoides, functions as a Proteasome Inhibitor. Bioorg. Med. Chem. Lett. 20 (11), 3341-3343 (2010).

6. Kapojos, M., Lee, J.-S., Oda, T., Nakazawa, T., Ukai, K., Mangindaan, R., Rotinsulu, H., Wewengkang, D., Tsukamoto, S., Kobayashi, H., Namikoshi, M. Two Unprecedented Cembrene-Type Terpenes from an Indonesian Soft Coral Sarcophyton sp. Tetrahedron 66 (3), 641-645 (2010).

Reviews

1. 塚本佐知子、横沢英良.タンパク質分解の不思議:ユビキチン‐プロテアソームシステムの仕組みと創薬.愛知学院大学薬学会誌 3, 1-18 (2010).

2. 塚本佐知子. 創薬を指向した天然薬物学研究. 薬学雑誌、130 (10), 1273-1281 (2010).

3. 塚本佐知子. 「石ころ」から「ダイヤ」? Notoamide の光学異性体の研究について. ファルマシア、46 (3) 235-240 (2010).

4. Tsukamoto, S., Yokosawa, H. Inhibition of the Ubiquitin-proteasome System by Natural Products for Cancer Therapy. Planta Med. 76 (11), 1064-1074 (2010).

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2009年

1. Wang, W., Takahashi, O., Oda, T., Nakazawa, T., Ukai, K., Mangindaan, R. E., Rotinsulu, H., Wewengkang, D. S., Kobayashi, H., Tsukamoto, S., Namikoshi, M. Lissoclibadins 8-14, Polysulfur Dopamine-derived Alkaloids from the Colonial Ascidian Lissoclinum cf. badium. Tetrahedron 65 (46), 9598-9603 (2009).

2. Wang, W., Lee, J.-S., Nakazawa, T., Ukai, K., Mangindaan, R. E. P., Wewengkang, D. S., Rotinsulu, H., Kobayashi, H., Tsukamoto, S., Namikoshi, M. (25S)-Cholesten-26-oic Acid Derivatives from an Indonesian Soft Coral Minabea sp. Steroids 74 (9), 758-760 (2009).

3. Dalisay, D. S., Tsukamoto, S., Molinsli, T. F. Absolute Configuration of the α,ω-Bifunctionalized Sphingolipid Leucettamol A from Leucetta sp. by Deconvoluted Exciton Coupled CD. J. Nat. Prod. 72 (3), 353-359 (2009).

4. Miller, K. A., Tsukamoto, S., Williams, R. M. Asymmetric Total Syntheses of (+)- and (-)-Versicolamide B and Biosynthetic Implications. Nat. Chem. 1, 63-68 (2009).

5. Tsukamoto, S., Kato, H., Greshock, T. J., Hirota, H., Ohta, T., Williams, R. M. Isolation of Notoamides E, a Key Precursor in the Biosynthesis of Prenylated Indole Alkaloids in a Marine-derived fungus, Aspergillus sp. J. Am. Chem. Soc. 131 (11), 3834-3835 (2009).

6. Tsukamoto, S., Kawabata, T., Kato, H., Greshock, T. J., Hirota, H., Ohta, T., Williams, R. M. Isolation of Antipodal (-)-Versicolamide B and Notoamides L-N from a Marine-derived Aspergillus sp. Org. Lett. 11 (6), 1297-1300 (2009).

7. Nakahashi, A., Miura, N., Monde, K., Tsukamoto, S. Stereochemical Studies of Hexylitaconic Acid, an Inhibitor of p53-HDM2 Interaction. Bioorg. Med. Chem. Lett. 19 (11), 3027-3030 (2009).

Review

1. Tsukamoto, S., Yokosawa, H. Targeting the proteasome-mediated proteolytic pathway, Expert Opin. Ther. Targets 13 (5), 605-621 (2009).

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2008年

1. Tsukamoto, S.,
Kato, H., Samizo, M., Nojiri, Y., Ohnuki, H., Hirota, H., Ohta, T. Notoamides F-K: Prenylated Indole Alkaloids Isolated from a Marine-derived Aspergillus sp. J. Nat. Prod. 71 (12), 2064-2067 (2008).

2. Tsukamoto, S., Takeuchi, T., Rotinsulu, H., Mangindaan, R. E. P., Soest, R. W. M. van, Ukai, K., Kobayashi, H., Namikoshi, M., Ohta, T., Yokosawa, H. Leucettamol A: A New Inhibitor of Ubc13-Uev1A Interaction Isolated from a Marine sponge, Leucetta aff. microrhaphis. Bioorg. Med. Chem. Lett. 18 (24), 6319-6320 (2008).

Reviews

1. 塚本佐知子. ユビキチンリガーゼを分子標的とする新規抗がん剤の海洋生物からの探索. 薬学研究の進歩研究成果報告集、24, 45-51 (2008).

2. 塚本佐知子、横沢英良. 展開するプロテアソーム阻害剤研究. 実験医学増刊「細胞内の輪廻転生 タンパク質の分解機構」、編集:田中啓二、羊土社、26, 122-127 (2008).

Book

1. 塚本佐知子. 抗ウイルス薬. 天然物化学:海洋生物編、監修:山村庄亮、長谷川宏司、木越英夫、アイピーシー、 pp 173-190 (2008).

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2007年

1. Tsukamoto, S., Kawabata, T., Kato, H., Ohta, T., Rotinsulu, H., Mangindaan, R. E. P., Soest, R. W. M. van, Ukai, K., Kobayashi, H., Namikoshi, M. Naamidines H and I: Cytotoxic Imidazole Alkaloids from the Indonesian Marine Sponge, Leucetta chagosensis, J. Nat. Prod. 70 (10), 1658-1660 (2007).

2. El-Beih, A. A., Kawabata, T., Koimaru, K., Ohta, T., Tsukamoto, S. Monodictyquinone A: A New Antimicrobial Anthraquinone from a Sea Urchin-Derived Fungus Monodictys sp., Chem. Pharm. Bull. 55 (7), 1097-1098 (2007).

3. El-Beih, A. A., Kato, H., Ohta, T., Tsukamoto, S. (3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin: A New Ramulosin Derivative from a Marine-derived Sterile Mycelium, Chem. Pharm. Bull. 55 (6), 953-954 (2007).

4. Greshock, T. J., Grubbs, A. W., Tsukamoto, S., Williams, R. M. A concise, Biomimetic Total Synthesis of Stephacidin A and Notoamide B. Angew. Chem. Int. Ed. 46 (13), 2262-2265 (2007).

5. Grubbs, W., Artman III, G. D., Tsukamoto, S., Williams, R. M. A concise Total Synthesis of the Notoamides C and D. Angew. Chem. Int. Ed. 46 (13), 2257-2261 (2007).

6. Kato, H., Yoshida, T., Tokue, T., Nojiri, Y., Hirota, H., Ohta, T., Williams, R. M., Tsukamoto, S. Notoamides A-D: New Prenylated Indole Alkaloids Isolated from a Marine-derived Fungus, Aspergillus sp. Angew. Chem. Int. Ed. 46 (13), 2254-2256 (2007).

7. El-Beih, A. A., Kato, H., Tsukamoto, S., Ohta, T. CYP3A4 Inhibitors Isolated from a Marine-derived Fungus, Penicillium species. J. Nat. Med. 61 (2), 175-177 (2007).

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2006年

1. Tokue, T., Miura, S., Kato, H., Hirota, H., Ohta, T., Tsukamoto, S. Neurotrophic Sesterterpenes Isolated from a Marine Sponge, Spongia sp. Heterocycles 69 (1), 521-526 (2006).

2. Matsumura, K., Nagano, M., Tsukamoto, S., Kato, H., Fusetani, N. Effect of Emetine, a Protein Synthesis Inhibitor, on Larval Tail Resorption in the Ascidian Halocynthia roretzi. Sessile Organisms 23 (2), 95-98 (2006).

3. Tsukamoto, S., Yoshida, T., Hosono, H., Ohta, T., Yokosawa, H. Hexylitaconic acid: A new inhibitor of p53-HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp. Bioorg. Med. Chem. Lett. 16 (1), 69-71 (2006).

Reviews

1. Tsukamoto, S. The Search for Inhibitors of the Ubiquitin-proteasome System from Natural Resources for Drug Development. J. Nat. Med. 60 (4), 273-278 (2006).

2. Tsukamoto, S., Yokosawa, H. Natural Products Inhibiting the Ubiquitin-proteasome Proteolytic Pathway, a Target for Drug Development. Curr. Med. Chem. 13 (7), 745-754 (2006).

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2005年

1. Tsukamoto, S., Aburatani, M., Yoshida, T., Yamashita, Y., El-beih, A. A., Ohta, T. CYP3A4 Inhibitors Isolated from Licorice. Biol. Pharm. Bull. 28 (10), 2000-2002 (2005).

2. Tsukamoto, S., Wakana, T., Koimaru, K. Yoshida, T., Sato, M., Ohta, T. 7-Hydroxy-3-(4-hydroxybenzyl)chroman and Broussonin B: Neurotrophic Compounds, Isolated from Anemarrhena asphodeloides BUNGE, Function as Proteasome Inhibitors. Biol. Pharm. Bull. 28 (9), 1798-1800 (2005).

3. Tsukamoto, S., Koimaru, K., Ohta, T. Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale. Mar. Drugs 3 (2), 29-35 (2005).

4. Tsukamoto, S., Aburatani, M., Ohta, T. Isolation of the Potent CYP3A4 Inhibitors from the Black Cohosh (Cimifunga racemosa). eCAM 2 (2), 223-226 (2005) .

5. Tsukamoto, S., Yamashita, Y., Ohta, T. New Cytotoxic and Antibacterial Compounds Isolated from the Sea Hare, Aplysia kurodai. Mar. Drugs 3 (2), 22-28 (2005).

6. Tsukamoto, S., Hirota, H., Imachi, M., Fujimuro, M., Onuki, H., Ohta, T., Yokosawa, H. Himeic Acid A: A New Ubiquitin-Activating Enzyme Inhibitor Isolated from a Marine-Derived Fungus, Aspergillus sp. Bioorg. Med. Chem. Lett. 15 (1), 191-194 (2005).

Book

1. 塚本佐知子. 第2章 医薬素材および研究用試薬、3.海綿. 海洋生物成分の利用─マリンバイオのフロンテイア─、監修:伏谷伸宏、シーエムシー出版、 pp 60-81 (2005).

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2004年

1. Tsukamoto, S., Tomise, K., Aburatani, M., Onuki, H., Hirota, H., Ishiharajima, E., Ohta, T. Isolation of Cytochrome P450 Inhibitors from Strawberry Fruit, Fragaria ananassa Duch. cv. Tochiotome. J. Nat. Prod. 67 (11), 1839-1841 (2004).

2. Tsukamoto, S., Yamashita, Y., Yoshida, T., Ohta, T. Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells. Mar. Drugs 2 (4), 170-175 (2004).

3. Tsukamoto, S., Yamashita, K., Tane, K., Kizu, R., Ohta, T., Matsunaga, S., Fusetani, N., Kawahara, H., Yokosawa, H. Girolline, an Antitumor Compound Isolated from a Sponge, Induces G2/M Cell Cycle Arrest and Accumulation of Polyubiquitinated p53. Biol. Pharm. Bull. 27 (5), 699-701 (2004)

4. Tsukamoto, S., Miura, S., Yamashita, Y., Ohta, T. Aspermytin A: A New Neurotrophic Polyketide Isolated from a Marine-derived Fungus of the Genus Aspergillus. Bioorg. Med. Chem. Lett. 14 (2), 417-420 (2004).

Review

1. 塚本佐知子、横沢英良. ユビキチン-プロテアソームシステムをターゲットとする天然物化学・創薬化学の新しい展開. 有機合成化学協会誌、62, 968-976 (2004).

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2003年

1. Tsukamoto, S., Macabalang, A. D., Nakatani, K., Obara, Y., Nakahata, N., Ohta, T. Tricholomalides A-C: New Neurotrophic Diterpenes from the Mushroom Tricholoma sp. J. Nat. Prod. 66 (12), 1578-1581 (2003).

2. Tsukamoto, S., Tatsuno, M., van Soest, R. W. M., Yokosawa, H., Ohta, T. New Polyhydroxy Sterols: Proteasome Inhibitors from a Marine Sponge Acanthodendrilla sp. J. Nat. Prod. 66 (9), 1181-1185 (2003).

3. Tsukamoto, S., Miura, S., van Soest, R. W. M., Ohta, T. Three New Cytotoxic Sesterterpenes from a Marine Sponge Spongia sp. J. Nat. Prod. 66 (3), 438-440 (2003).

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2002年

1. Ohta, T., Miyamoto, Y., Maruyama, T., Kiuchi, F., Tsukamoto, S. Localization and Contents of Paradisins, the Most Potent CYP3A4 Inhibitors, in a Grapefruit Citrus paradisii and Grapefruit Juice. Nat. Med. 56 (6), 264-267 (2002).

2. Ohta, T., Maruyama, T., Nagahashi, K., Miyamoto, Y., Hosoi, S., Kiuchi, F., Yamazoe, Y., Tsukamoto, S. Paradisin C: A New CYP3A4 Inhibitor from Grapefruit Juice. Tetrahedron 58 (33), 6631-6635 (2002).

3. Tsukamoto, S., Tomise, K., Miyakawa, K., Cha, B.-C., Abe, T., Hamada, T., Hirota, H., Ohta, T. CYP3A4 Inhibitory Activity of New Bisalkaloids Dipiperamides D and E and Cognate Alkaloids from the White Pepper. Bioorg. Med. Chem. 10 (9), 2981-2985 (2002).

4. Ohta, T., Nagahashi, M., Hosoi, S., Tsukamoto, S. Dihydroxybergamottin Caproate as a Potent and Stable CYP3A4 Inhibitor. Bioorg. Med. Chem. 10 (4), 969-973 (2002).

5. Tsukamoto, S., Cha, B.-C., Ohta, T. Dipiperamides A, B, and C: bisalkaloids from the white pepper Piper nigrum inhibiting CYP3A4 activity. Tetrahedron 58 (9), 1667-1671 (2002).

6. Tsukamoto, S., Macabalang, A. D., Abe, T., Hirota, H., Ohta, T. Thelephorin A: a new radical scavenger from the mushroom Thelephora vialis. Tetrahedron 58 (6), 1103-1105 (2002).

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2001年

1. Tsukamoto, S., Tane, K., Ohta, T., Matsunaga, S., Fusetani, N., van Soest, R. W. M. Four New Bioactive Pyrrole-derived Alkaloids from the Marine Sponge Axinella brevistyla. J. Nat. Prod. 64 (12), 1576-1578 (2001).

Book

1. Tsukamoto, S., Kato, H., Hirota, H., Fusetani, N. Lumichrome is a Putative Intrinsic Substance Inducing Larval Metamorphosis in the Ascidian Halocynthia roretzi. The Biology of Asicidians; Sawada, H., Yokosawa, H., Lambert, C. C. Eds.; Springer-Verlag. Tokyo: Tokyo; pp 335-340 (2001).

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